Article

Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to C hlamydia trachomatis

2013-06-25

Abstract excerpt

Summary The mechanistic details of the pathogenesis of Chlamydia, an obligate intracellular pathogen of global importance, have eluded scientists due to the scarcity of traditional molecular genetic tools to investigate this organism. Here we report a chemical biology strategy that has uncovered the first essential protease for this organism. Identification and application of a unique CtHtrA inhibitor (JO146) to c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 00855baa-80d8-59bf-a63a-1e02d44a0b7e
DOI: 10.1111/mmi.12306

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to C hlamydia trachomatisDOI 10.1111/mmi.12306Read

The Periplasmic Tail-Specific Protease, Tsp, Is Essential for Secondary Differentiation in Chlamydia trachomatisSemantic proximity Read

A renewed tool kit to explore Chlamydia pathogenesis: from molecular genetics to new infection modelsSemantic proximity Read

Initial Characterization of the Two ClpP Paralogs of Chlamydia trachomatis Suggests Unique Functionality for EachSemantic proximity Read

The inclusion membrane protein IncS is critical for initiation of the Chlamydia intracellular developmental cycleSemantic proximity Read

Absence of Specific Chlamydia trachomatis Inclusion Membrane Proteins Triggers Premature Inclusion Membrane Lysis and Host Cell Death.Semantic proximity Read

A genome-wide genetic screen identified targets for destabilizing the parasitophorous vacuole of Chlamydia trachomatisSemantic proximity Read

New Frontiers in Type III Secretion Biology: the Chlamydia PerspectiveSemantic proximity Read

Homologues of the Chlamydia trachomatis and Chlamydia muridarum Inclusion Membrane Protein IncS Are Interchangeable for Early Development but Not for Inclusion Stability in the Late Developmental CycleSemantic proximity Read

Insights into Chlamydia Development and Host Cells ResponseSemantic proximity Read

Pathogenicity and virulence of Chlamydia trachomatis : Insights into host interactions, immune evasion, and intracellular survivalSemantic proximity Read

Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatisSemantic proximity Read

Molecular pathogenesis of Chlamydia trachomatisSemantic proximity Read