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Article

Strain-specific effects of Desulfovibrio on neurodegeneration and oxidative stress in a Caenorhabditis elegans PD model

11 Aug 2025

Abstract excerpt

The gut microbiota is increasingly recognized as a key contributor to intestinal and brain pathologies, including Parkinson's disease (PD). Sulfate-reducing Desulfovibrio (DSV) species have emerged as microbial drivers through hydrogen sulfide and other neurotoxic factors. Using the Caenorhabditis elegans PD model NL5901 expressing human α-synuclein, we examined the effects of six DSV strains from human, animal,...

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PMID: 40790298
DOI: 10.1038/s41531-025-01102-z

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