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Article

Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: phase 1 AMPLIFY-201 trial final results.

Nature medicine - 1 Nov 2025

Wainberg Zev A, Weekes Colin D, Furqan Muhammad, Kasi Pashtoon M, Devoe Craig E, Leal Alexis D, Chung Vincent, Perry James R, Kheoh Thian, McNeil Lisa K, Welkowsky Esther, DeMuth Peter C, Haqq Christopher M, Pant Shubham, O'Reilly Eileen M

Abstract excerpt

Cellular immunity, mediated by tumor antigen-specific CD4+ and CD8+ T cells, has a critical role in the success of cancer immunotherapy by targeting intracellular driver and passenger tumor mutations. We present the final results of the phase 1 AMPLIFY-201 trial, in which patients who completed standard locoregional treatment, with minimal residual mKRAS disease (n = 25, 20 pancreatic cancer and 5 colorectal...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40790272
DOI: 10.1038/s41591-025-03876-4
PMCID: PMC12618236

Genes

CD4
KRAS

Variants

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