Article
CYP2C19 genotype-directed P2Y12 inhibitor antiplatelet therapy normalizes risk for major adverse cardiovascular events after percutaneous coronary intervention.
Indian heart journal - 1 Jan 2000
Stys Tomasz P, Gedela Maheedhar, Gowda Smitha N, Bares Valerie, Fanta Lauren, Petrasko Marian, Hajek Catherine, Larson Eric, Stys Adam T
Abstract excerpt
OBJECTIVE: To study the use of CYP2C19 genotyping to guide P2Y12 inhibitor selection to maximize efficacy, and attenuate risk in appropriate patients who underwent PCI for CAD. METHODS: We performed a retrospective analysis of 868 patients with CAD who received CYP2C19 genotyping after PCI and changed P2Y12 inhibitor based on the results. Patients were divided into two groups based on clopidogrel metabolizer...
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