Association of TNFRSF12A Methylation With Prognosis in Hepatocellular Carcinoma With History of Alcohol Consumption

Abstract excerpt

Background: Hepatocellular carcinoma (HCC) is the third most common cause of mortality worldwide with a poor prognosis. Alcoholic liver disease accounts for approximately one-third of all HCC cases. TNFRSF12A hepatic expression correlates with disease severity. Overexpression of TNFRSF12A in HCC might be an indicator of more aggressive tumours and worse clinical outcomes. Epigenetic mechanisms including...

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