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Extracellular matrix remodeling fibroblasts govern the tumor microenvironment disparity between adenomatous lesions and adenocarcinoma in gallbladder

18 Jul 2025

Abstract excerpt

Introduction: Gallbladder cancer (GBC) is a highly lethal cancer with a poor prognosis. The adenoma-carcinoma sequence is a recognized model for GBC development, but its underlying mechanisms are not well understood. Methods: Human specimens were collected from Shengjing Hospital of China Medical University. Single-cell isolation and sequencing were conducted on cells from four GBC and four gallbladder...

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PMID: 40755770
DOI: 10.3389/fimmu.2025.1637300

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