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T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome

2 Jul 2025

Abstract excerpt

alanine scanning highlighted the functional importance of mutationally constrained immunodominant regions. Collectively, these findings identify immunodominant T cell epitopes across the SARS-CoV-2 proteome that may enhance immune surveillance against emerging variants and inform next-generation vaccine designs providing broader and more durable protection.

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Identifiers

PMID: 40746995
DOI: 10.1016/j.isci.2025.113044

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