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Polypeptides synthesized by common bacteria in the human gut improve rodent metabolism

31 Jul 2025

Abstract excerpt

The human gut microbiota has the potential to synthesize proteins that may influence host metabolism. Here we report two polypeptides, RUMTOR-derived peptide (RORDEP) 1 and RORDEP2, circulating in human blood and synthesized by specific strains of gut commensal Ruminococcus torques that correlate inversely with adiposity in humans. Oral gavage with RORDEP-expressing strains improved glucose tolerance, increased...

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PMID: 40745048
DOI: 10.1038/s41564-025-02064-x

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