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Elevated mevalonolactone from Ruminococcus torques contributes to metabolically unhealthy obesity development

22 May 2025

Abstract excerpt

Obese individuals are categorized as either "Metabolically Unhealthy Obesity" (MUO) or "Metabolically Healthy Obesity" (MHO) based on their insulin resistance and metabolic disorders. However, the intrinsic mechanism remains largely unknown. By examining gut microbiota and fecal metabolome of patients with MUO and MHO, we identified intestinal microorganism Ruminococcus torques (R. torques) and its metabolite...

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PMID: 40412522
DOI: 10.1016/j.jbc.2025.110281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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