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GLP-1RAs attenuated obesity and reversed leptin resistance partly via activating the microbiome-derived inosine/A2A pathway

9 Dec 2024

Abstract excerpt

Extensive evidence has demonstrated that glucagon-like peptide-1 receptor agonists (GLP-1RAs) can ameliorate obesity. Our previous studies revealed that (Ex-4) 2 -Fc, a long-acting GLP-1RA we developed, depends on the leptin pathway to treat obesity. However, the mechanisms linking (Ex-4) 2 -Fc and leptin resistance remain largely unclear. To address this question, we explored the mechanism of GLP-1RAs from the...

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PMID: 40177547
DOI: 10.1016/j.apsb.2024.12.006

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