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Article

Sex-specific nicotine sensitization and imprinting of self-administration in rats inform GWAS findings on human addiction phenotypes.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Sept 2021

Kozlova Alena, Butler Robert R, Zhang Siwei, Ujas Thomas, Zhang Hanwen, Steidl Stephan, Sanders Alan R, Pang Zhiping P, Vezina Paul, Duan Jubao

Abstract excerpt

Repeated nicotine exposure leads to sensitization (SST) and enhances self-administration (SA) in rodents. However, the molecular basis of nicotine SST and SA and their biological relevance to the mounting genome-wide association study (GWAS) loci of human addictive behaviors are poorly understood. Considering a gateway drug role of nicotine, we modeled nicotine SST and SA in F1 progeny of inbred rats (F344/BN)...

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Identifiers

PMID: 34007041
DOI: 10.1038/s41386-021-01027-0
PMCID: PMC8358005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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