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Article

Genomic characterization of clonal B-cell lymphocytosis of marginal zone origin with MYC rearrangements.

Virchows Archiv : an international journal of pathology - 1 Apr 2026

Diez-Feijóo Ramón, Teixidó Mar, Ferrer Ana, Lafuente Marta, Rodriguez-Rivera María, Puiggros Anna, Calvo Xavier, Colomo Luis, Tazón-Vega Bárbara, López Cristina, Clot Guillem, Sanchez-Gonzalez Blanca, Ferrá Christelle, Bellosillo Beatriz, Espinet Blanca, Salar Antonio, Salido Marta

Abstract excerpt

Monoclonal B-cell lymphocytosis of marginal zone origin (MBL-MZ) is an indolent clonal disorder with potential progression to lymphoma. MYC rearrangements (MYCr), typically linked to aggressive B-cell lymphomas, have not been reported in MBL-MZ. We describe three MBL-MZ cases with MYCr and TP53 alterations, detected via karyotyping, FISH, and optical genome mapping. We genetically characterized these cases by NGS...

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Topics

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Share to B-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to In Situ Hybridization, Fluorescence

Share to Lymphocytosis

Share to Lymphoma, B-Cell, Marginal Zone

Share to Proto-Oncogene Proteins c-myc

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 40728545
DOI: 10.1007/s00428-025-04195-2

Genes

MYC
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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