Aging and Viral Evolution Impair Immunity Against Dominant Pan-Coronavirus-Reactive T Cell Epitope.

doi:10.1002/eji.202551888

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Article

Aging and Viral Evolution Impair Immunity Against Dominant Pan-Coronavirus-Reactive T Cell Epitope.

European journal of immunology - 1 Jul 2025

Loyal Lucie, Jürchott Karsten, Reimer Ulf, Meyer-Arndt Lil, Henze Larissa, Mages Norbert, Kostrzanowski Jak, Reus Bernhard, Mangold Maike, Kruse Beate, Dingeldey Manuela, Sawitzki Birgit, Michel Janine, Grossegesse Marica, Schnatbaum Karsten, Wenschuh Holger, Nitsche Andreas, Lachmann Nils, Timmermann Bernd, Giesecke-Thiel Claudia, Braun Julian, Kern Florian, Thiel Andreas

Abstract excerpt

Immune evasion by escape mutations subverts immunity against SARS-CoV-2. A role of pan-coronavirus immunity for more durable protection is being discussed, but has remained understudied. We here investigated the effects of age, mutations, and homo-/heterologous vaccination regimens on the dominant pan-coronavirus-specific cellular and humoral epitope iCope after SARS-CoV-2 infection and vaccination in detail. In...

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PMID: 40726062
DOI: 10.1002/eji.202551888
PMCID: PMC12304627

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