Article
HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2.
Communications biology - 6 Sept 2022
Olafsdottir Thorunn A, Bjarnadottir Kristbjorg, Norddahl Gudmundur L, Halldorsson Gisli H, Melsted Pall, Gunnarsdottir Kristbjorg, Ivarsdottir Erna, Olafsdottir Thorhildur, Arnthorsson Asgeir O, Theodors Fannar, Eythorsson Elias, Helgason Dadi, Eggertsson Hannes P, Masson Gisli, Bjarnadottir Sólveig, Saevarsdottir Saedis, Runolfsdottir Hrafnhildur L, Olafsson Isleifur, Saemundsdottir Jona, Sigurdsson Martin I, Ingvarsson Ragnar F, Palsson Runolfur, Thorgeirsson Gudmundur, Halldorsson Bjarni V, Holm Hilma, Kristjansson Mar, Sulem Patrick, Thorsteinsdottir Unnur, Jonsdottir Ingileif, Gudbjartsson Daniel F, Stefansson Kari
Abstract excerpt
Memory T-cell responses following SARS-CoV-2 infection have been extensively investigated but many studies have been small with a limited range of disease severity. Here we analyze SARS-CoV-2 reactive T-cell responses in 768 convalescent SARS-CoV-2-infected (cases) and 500 uninfected (controls) Icelanders. The T-cell responses are stable three to eight months after SARS-CoV-2 infection, irrespective of disease...
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