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Article

HPV 16 detection in cervical lesions, physical state of viral DNA and changes in p53 gene.

Sao Paulo medical journal = Revista paulista de medicina - 5 Mar 2003

do Horto dos Santos Oliveira Ledy, Rodrigues Eliane de Vasconcelos Machado, de Salles Lopes Ana Paula Terra Alvim, Fernandez André de Paula, Cavalcanti Silvia Maria Baeta

Abstract excerpt

CONTEXT: Persistent infection with high risk human papillomavirus (HPV) has been linked to cervical carcinoma. Integration of viral DNA into host cell DNA is essential for this cancer development, promoting disruption of the HPV E2 gene, thus leading to unregulated increases in E6 and E7 proteins and inactivating the products of p53 and Rb tumor suppressor genes. OBJECTIVE: To investigate HPV 16 infection in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12870053
DOI: 10.1590/s1516-31802003000200007
PMCID: PMC11108634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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