Back to search

Article

Sarsasapogenin ameliorates diabetes-associated memory impairment and neuroinflammation through inhibiting thrombin/PAR-1 pathway

2020-01-17

Abstract excerpt

<title>Abstract</title> <p>Background: Sarsasapogenin (Sar), a natural steroidal compound, shows neuroprotective, promoting cognition, anti-inflammatory, anti-thrombosis effects, etc. However, whether Sar can ameliorate diabetes-associated cognitive impairment and whether it is related to the anti-inflammatory and anti-thrombosis effects of Sar, it remains unknown. <h4>Methods:</h4> Streptozotocin-induced diabeti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7b355d02-c0f6-5b4c-b39b-99795c280e04
DOI
10.21203/rs.2.21148/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Sarsasapogenin ameliorates diabetes-associated memory impairment and neuroinflammation through inhibiting thrombin/PAR-1 pathwayDOI 10.21203/rs.2.21148/v1
Neuroinflammation and Neovascularization in diabetic eye diseases (DEDs): Identification of potential pharmacotherapeutic targetsSemantic proximity
C5aR1 mediates progression of inflammatory responses in brain of rats after ischemia and reperfusionSemantic proximity
RNA-seq analysis of ischemia stroke and normal brain in a tree shrew model with or without type 2 diabetes mellitusSemantic proximity
Pathological pathway and protective mechanisms of phytobioactives used in diabetic retinopathy: A reviewSemantic proximity
Effect of Pioglitazone on Expression of Interleukin-17A, Toll-like receptor 2, Inducible nitric oxide synthase 2 and Arginase 1 in Alzheimeric-model of rats Brain.Semantic proximity
Jiao-tai-wan and its effective component-coptisine alleviate cognitive impairment in db/db mice through the JAK2/STAT3 signaling pathwaySemantic proximity
From Malaria Fighter to Diabetes Guardian: The Emerging Role of Artesunate in Treating Diabetes and Diabetic ComplicationsSemantic proximity
Severe Hypoglycemia Contributing to Cognitive Dysfunction in Diabetic Mice is Associated with Pericyte and Blood–Brain Barrier DysfunctionSemantic proximity
Ameliorative Effects of Arctigenin From Arctium Lappa L Against LPS-induced Neuroinflammation and Cognitive Impairments in MiceSemantic proximity
Mechanisms of action of formononetin, an extract from Astragalus membranaceus medicinal plant, in ameliorating Alzheimer’s diseaseSemantic proximity
Rolipram and Pentoxifylline Combination Ameliorates Experimental Diabetic Neuropathy Through Inhibition of Oxidative Stress and Inflammatory Pathways in the Dorsal Root Ganglion NeuronsSemantic proximity
Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.Semantic proximity
Select a neighboring publication to make it the new centre.