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HIV drug resistance in children and adolescents on NNRTI-based antiretroviral therapy and subsequent virologic response to dolutegravir-based regimens in Ghana.

AIDS research and therapy - 26 Jul 2025

Afrane Adwoa K A, Novitsky Vlad, Hague Joel, Sagoe Kwamena, Alhassan Yakubu, Dame Joycelyn Assimeng, Martyn-Dickens Charles, Lartey Margaret, Goka Bamenla, Torpey Kwasi, Kantor Rami, Kwara Awewura

Abstract excerpt

HIV drug resistance (HIVDR) was retrospectively characterized among 20 children and adolescents with HIV with virologic failure on non-nucleoside reverse transcriptase inhibitor (NNRTI)-based therapy, and virologic response in those switched to dolutegravir (DTG)-based therapy described. All participants had at least one NNRTI resistance mutation, most commonly K103N (N = 12) and 15 (75%) had nucleoside reverse...

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PMID: 40713598
DOI: 10.1186/s12981-025-00762-4
PMCID: PMC12296613

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