Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole genome sequencing reveals novel resistance-conferring mutations and large genome deletions in drug-resistant Mycobacterium tuberculosis isolates from Indonesia.

Journal of global antimicrobial resistance - 1 Sept 2025

Aung Htin Lin, Chaidir Lidya, Pitaloka Dian Ayu Eka, Miyahara Yugen, Kumar Narender, Soeroto Arto Yuwono, Cook Greg M, van Crevel Reinout, Alisjahbana Bachti, Peacock Sharon J, Hill Philip C

Abstract excerpt

OBJECTIVE: This study evaluated drug resistance profiles of Mycobacterium tuberculosis (Mtb) isolates in West Java, Indonesia through phenotypic and genomic approaches. METHODS: We performed phenotypic drug-susceptibility testing (DST), coupled with whole-genome sequencing (WGS) of 142 Mtb isolates identified as RIF-R (Rifampicin resistant) using the Xpert MTB/RIF platform. RESULTS: We found 107/142 (75%)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antitubercular Agents
Share to Catalase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple, Bacterial

Share to Indonesia

Share to Isoniazid

Share to Rifampin

Share to Tuberculosis, Multidrug-Resistant

Share to Whole Genome Sequencing

Source

Identifiers

PMID: 40706998
DOI: 10.1016/j.jgar.2025.07.017

Genes

DST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole genome sequencing reveals novel resistance-conferring mutations and large genome deletions in drug-resistant Mycobacterium tuberculosis isolates from Indonesia.PMID 40706998Read ↗

Use of whole-genome sequencing to predict Mycobacterium tuberculosis drug resistance in Indonesia.Semantic proximity Read ↗

Analytical concordance of targeted next-generation sequencing and whole-genome sequencing for <i>Mycobacterium tuberculosis</i> drug resistance and lineage determination in West Java, IndonesiaSemantic proximity Read ↗

Whole-genome sequencing analysis of multidrug-resistant Mycobacterium tuberculosis from Java, Indonesia.Semantic proximity Read ↗

The whole-genome sequencing in predicting Mycobacterium tuberculosis drug susceptibility and resistance in Papua, Indonesia.Semantic proximity Read ↗

Whole-Genome and Targeted Sequencing of 75 Drug-Resistant Mycobacterium tuberculosis Clinical Isolates in South Korea.Semantic proximity Read ↗

Mycobacterium tuberculosis Lineage Distribution Using Whole‐Genome Sequencing and Bedaquiline, Clofazimine, and Linezolid Phenotypic Profiles among Rifampicin‐Resistant Isolates from West Java, IndonesiaSemantic proximity Read ↗

Whole Genome Sequencing of Clinical Samples Reveals Extensively Drug Resistant Tuberculosis (XDR TB) Strains From The Beijing Lineage in Nigeria, West Africa.Semantic proximity Read ↗

Molecular epidemiology study of Mycobacterium tuberculosis and its susceptibility to anti-tuberculosis drugs in Indonesia.Semantic proximity Read ↗

Whole-genome sequencing of clinical isolates from tuberculosis patients in India: real-world data indicates a high proportion of pre-XDR cases.Semantic proximity Read ↗

Genotypic drug resistance using whole-genome sequencing of Mycobacterium tuberculosis clinical isolates from North-western Tanzania.Semantic proximity Read ↗

Unearthing novel mutations and genetic variation in drug sensitive and resistant isolates of Mycobacterium tuberculosis through whole genome sequencing: A study from eastern Uttar Pradesh, India.Semantic proximity Read ↗

Whole genome sequencing of Mycobacterium tuberculosis for detection of drug resistance: a systematic review.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.