Article

Transcriptomic plasticity is a hallmark of metastatic pancreatic cancer

2025-03-06

Abstract excerpt

Metastasis is the leading cause of cancer deaths; nonetheless, how tumor cells adapt to vastly different organ contexts is largely unknown. To investigate this question, we generated a transcriptomic atlas of primary tumor and diverse metastatic samples from a patient with pancreatic ductal adenocarcinoma who underwent rapid autopsy. Unsupervised archetype analysis identified both shared and site-specific gene pro...

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Literature Corpus work: 09840c78-54a8-5dfe-a465-15e725d74d58
DOI: 10.1101/2025.02.28.640922

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