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Article

Asperosaponin VI mitigates mitochondrial dysfunction and chondrocyte apoptosis in osteoarthritis by modulating the AMPK-SIRT3 pathway

23 Jul 2025

Abstract excerpt

OBJECTIVE: To investigate the therapeutic potential of Asperosaponin VI (ASA VI) from Clematis chinensis in mitigating osteoarthritis (OA) progression by modulating the AMPK-SIRT3 pathway, specifically addressing ER stress, mitochondrial dysfunction, and chondrocyte apoptosis. METHODS: In vitro studies were conducted using tert-Butyl hydroperoxide (TBHP)-treated chondrocytes to evaluate the effects of ASA VI on...

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PMID: 40702216
DOI: 10.1007/s10565-025-10071-1

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