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Astragalus-Angelica sinensis-Derived Extracellular Vesicles Attenuate Knee Osteoarthritis with Periarticular Muscle Atrophy via PPARγ-Mediated Regulation of Skeletal Muscle Fatty Acid Metabolism

2026-08-20

Abstract excerpt

<title>Abstract</title> <p>Knee osteoarthritis (KOA) is frequently accompanied by periarticular muscle atrophy. Targeting muscle atrophy holds promise for delaying KOA progression; however, therapeutic strategies that simultaneously protect both muscle and joint remain scarce. The traditional Chinese formula Danggui Buxue Decoction (DBD) shows potential in attenuating KOA-associated muscle atrophy, yet its clinic...

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Literature Corpus work: 31c92944-fbef-56e6-87c8-6bd9f27a2a84
DOI: 10.21203/rs.3.rs-10556770/v1

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