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Article

The colorectal liver metastasis growth pattern phenotype is not dependent on genotype.

British journal of cancer - 1 Oct 2025

Höppener Diederik J, Verheul Sanne M L, Nierop Pieter M H, Buisman Florian E, Galjart Boris, Wilting Saskia M, Pugh Siân A, Richman Susan D, Balachandran Vinod P, Jarnagin William R, Kingham T Peter, Vermeulen Peter B, Shia Jinru, Quirke Philip, Bridgewater John A, Maughan Timothy S, Groot Koerkamp Bas, Grünhagen Dirk J, Verhoef Cornelis, Primrose John N, D'Angelica Michael I

Abstract excerpt

BACKGROUND: The histopathological growth patterns (HGPs) of colorectal cancer liver metastases broadly classify patients into two groups post-liver metastasectomy, with encapsulated HGP indicating a more favourable prognosis. The potential association between HGPs and specific mutations is poorly understood. METHODS: Using next-generation sequencing data of 461 resected patients (104 patients with encapsulated...

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Identifiers

PMID: 40702107
DOI: 10.1038/s41416-025-03103-4
PMCID: PMC12480539

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B2M
BRAF
KRAS
NRAS
POLE
PTEN

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