Histopathological Growth Patterns and Survival After Resection of Colorectal Liver Metastasis: An External Validation Study.

doi:10.1093/jncics/pkab026

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Article

Histopathological Growth Patterns and Survival After Resection of Colorectal Liver Metastasis: An External Validation Study.

JNCI cancer spectrum - 1 Jun 2021

Höppener Diederik J, Galjart Boris, Nierop Pieter M H, Buisman Florian E, van der Stok Eric P, Coebergh van den Braak Robert R J, van Amerongen Martin J, Balachandran Vinod P, Jarnagin William R, Kingham T Peter, Doukas Michail, Shia Jinru, Nagtegaal Iris D, Vermeulen Peter B, Koerkamp Bas Groot, Grünhagen Dirk J, de Wilt Johannes H W, D'Angelica Michael I, Verhoef Cornelis

Abstract excerpt

Background: After resection of colorectal cancer liver metastases (CRLM), 2 main histopathological growth patterns can be observed: a desmoplastic and a nondesmoplastic subtype. The desmoplastic subtype has been associated with superior survival. These findings require external validation. Methods: An international multicenter retrospective cohort study was conducted in patients treated surgically for CRLM at 3...

Topics

Antineoplastic Agents
Colorectal Neoplasms
Confidence Intervals
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Microsatellite Instability

Netherlands

Phenotype

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

Retrospective Studies

United States

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Identifiers

PMID: 34056541
DOI: 10.1093/jncics/pkab026
PMCID: PMC8152695

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