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Article

Changes in the Immune Phenotype and Gene Expression Profile Driven by a Novel Tuberculosis Nanovaccine: Short and Long-Term Post-immunization.

Frontiers in immunology - 1 Jan 2020

Martínez-Pérez Amparo, Igea Ana, Estévez Olivia, Ferreira Catarina M, Torrado Egídio, Castro António Gil, Fernández Carmen, Spetz Anna-Lena, Adam Lucille, López González Moisés, Singh Mahavir, Reljic Rajko, González-Fernández África

Abstract excerpt

Deciphering protection mechanisms against Mycobacterium tuberculosis (Mtb) remains a critical challenge for the development of new vaccines and therapies. We analyze the phenotypic and transcriptomic profile in lung of a novel tuberculosis (TB) nanoparticle-based boosting mucosal vaccine Nano-FP1, which combined to BCG priming conferred enhanced protection in mice challenged with low-dose Mtb. We analyzed the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33584654
DOI: 10.3389/fimmu.2020.589863
PMCID: PMC7876410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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