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Astragalin promotes HSCs ferroptosis through NCOA4 mediated ferritinophagy to alleviate liver fibrosis in zebrafish and mice

21 Jul 2025

Abstract excerpt

Liver fibrosis is pathological progression of chronic liver disease. Recent research has focused on the activation of hepatic stellate cells (HSCs), highlighting their potential as targets for mitigating fibrosis. While herbal medicines and natural active ingredients have shown promising anti-fibrotic effects in clinical treatments, the impact of Astragalin (Ag) remains unexplored. In this study, we established...

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PMID: 40691373
DOI: 10.1038/s42003-025-08421-0

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