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Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI

21 Jul 2025

Abstract excerpt

Abstract As a cardinal marker of brain ageing, lifetime brain atrophy obtained from a cross-sectional magnetic resonance image promises to boost statistical power to uncover novel genetic mechanisms of neurodegeneration. By analysing five young and old adult cohorts, we perform the most definitive study on lifetime brain atrophy’s measurement and correlates. It is simply calculated from the relationship between...

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PMID: 40691153
DOI: 10.1038/s41467-025-61978-6

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