Article

Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates

2024-11-07

Abstract excerpt

A measure of lifetime brain atrophy (LBA) obtained from a single magnetic resonance imaging (MRI) scan could be an attractive candidate to boost statistical power in uncovering novel genetic signals and mechanisms of neurodegeneration. We analysed data from five young and old adult cohorts (MRi-Share, Human Connectome Project, UK Biobank, Generation Scotland Subsample, and Lothian Birth Cohort 1936 [LBC1936]) to t...

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Literature Corpus work: 5f1e4060-60fd-5f5e-8421-4b9ef1fd9ff0
DOI: 10.1101/2024.11.06.622274

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