Individual variations in 'brain age' relate to early-life factors more than to longitudinal brain change.

doi:10.7554/eLife.69995

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Article

Individual variations in 'brain age' relate to early-life factors more than to longitudinal brain change.

eLife - 10 Nov 2021

Vidal-Pineiro Didac, Wang Yunpeng, Krogsrud Stine K, Amlien Inge K, Baaré William F C, Bartres-Faz David, Bertram Lars, Brandmaier Andreas M, Drevon Christian A, Düzel Sandra, Ebmeier Klaus, Henson Richard N, Junqué Carme, Kievit Rogier Andrew, Kühn Simone, Leonardsen Esten, Lindenberger Ulman, Madsen Kathrine S, Magnussen Fredrik, Mowinckel Athanasia Monika, Nyberg Lars, Roe James M, Segura Barbara, Smith Stephen M, Sørensen Øystein, Suri Sana, Westerhausen Rene, Zalesky Andrew, Zsoldos Enikő, Walhovd Kristine Beate, Fjell Anders

Abstract excerpt

Brain age is a widely used index for quantifying individuals' brain health as deviation from a normative brain aging trajectory. Higher-than-expected brain age is thought partially to reflect above-average rate of brain aging. Here, we explicitly tested this assumption in two independent large test datasets (UK Biobank [main] and Lifebrain [replication]; longitudinal observations ≈ 2750 and 4200) by assessing the...

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PMID: 34756163
DOI: 10.7554/eLife.69995
PMCID: PMC8580481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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