Digital FDG-PET Detects MYD88 Mutation-Driven Glycolysis in Primary CNS Lymphoma.

doi:10.3174/ajnr.A8935

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Article

Digital FDG-PET Detects MYD88 Mutation-Driven Glycolysis in Primary CNS Lymphoma.

AJNR. American journal of neuroradiology - 5 Jan 2026

Sasaki Mayu, Teraoka Yuri, Kato Ayumi, Nakajima Tadaaki, Ishiwata Yoshinobu, Miyake Yohei, Honma Hirokuni, Nakamura Taishi, Ikegaya Naoki, Takayama Yutaro, Yazawa Osamu, Sawamura Shungo, Oshima Akito, Hayashi Hiroaki, Ye WeiKai, Sasaoka Kanoko, Yoshii Yukie, Fujii Satoshi, Tateishi Ukihide, Yamamoto Tetsuya, Utsunomiya Daisuke, Kato Shingo, Tateishi Kensuke

Abstract excerpt

BACKGROUND AND PURPOSE: The relationship between digital 18F-FDG-PET findings and glucose metabolism-related genetic alterations remains unclear in primary CNS lymphoma (PCNSL). This study aimed to evaluate whether digital FDG-PET can serve as a noninvasive tool to detect MYD88 mutation-driven glycolytic activity in PCNSL. MATERIALS AND METHODS: We retrospectively analyzed the imaging and molecular data of 54...

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Identifiers

PMID: 40691089
DOI: 10.3174/ajnr.A8935
PMCID: PMC12767727

Genes

MYD88

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