Article
Frequency of MYD88 and CD79B mutations, and MGMT methylation in primary central nervous system diffuse large B-cell lymphoma.
Neuropathology : official journal of the Japanese Society of Neuropathology - 1 Dec 2017
Zheng Mei, Perry Anamarija M, Bierman Philip, Loberiza Fausto, Nasr Michel R, Szwajcer David, Del Bigio Marc R, Smith Lynette M, Zhang Weiwei, Greiner Timothy C
Abstract excerpt
Primary CNS diffuse large B-cell lymphoma (PCNS-DLBCL) and systemic DLBCL harbor mutations in MYD88 and CD79B. DNA methyltransferase (MGMT) is methylated in some DLBCL. Our goal was to investigate the frequencies of these events, which have not been previously reported within the same series of patients with PCNS-DLBCL. Fifty-four cases of PCNS-DLBCL from two institutions were analyzed by Sanger sequencing for...
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