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Article

Impact of ABCB1 gene polymorphism on clopidogrel plasma concentration and cardiovascular events in post-PCI patients.

Pharmacogenomics - 1 Jan 2026

Razaq Abdur, Iqbal Waheed, Shah Syed Tahir, Abdur Rauf Muhammad, Aldekhail Nasser M, Van Nieuwerburgh Filip, Siraj Sami

Abstract excerpt

AIM: This study investigated the impact of ABCB1 gene polymorphisms on clopidogrel absorption and therapeutic response by analyzing plasma levels of the clopidogrel carboxylic acid metabolite (CAM), and cardiovascular events (CVEs) in patients undergoing percutaneous coronary intervention (PCI). METHODS: A prospective cohort study of 264 post-PCI patients was conducted in Peshawar, Pakistan. CVEs over 12 months...

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Aged
ATP Binding Cassette Transporter, Subfamily B
Cardiovascular Diseases
Clopidogrel
Percutaneous Coronary Intervention

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Platelet Aggregation Inhibitors

Polymorphism, Single Nucleotide

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Open in PubMed Open full text

Identifiers

PMID: 40689604
DOI: 10.1080/14622416.2025.2534325
PMCID: PMC13374772

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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