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Study on the effect of CYP2C19 genetic polymorphism and plasma concentration on clopidogrel resistance.

Pakistan journal of pharmaceutical sciences - 1 Sept 2021

Wu Hui, Chen Xinli, Ding Yongli, Deng Yanglin, Ma Ruilan, Chen Xinyuan, Li Xuesong

Abstract excerpt

At present, the mechanism for clopidogrel resistance (CR) is incompletely understood. Here, we aimed to analyze of the association of plasma concentration of clopidogrel active metabolites (CAM) and CYP2C19 genetic polymorphism with CR. We assigned 77 patients to receive CLP at a loading dose of 300mg on day 1, followed by 75mg per day from day 2 to day 6. Three peripheral venous blood samples were collected for...

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Aged
Clopidogrel
Cytochrome P-450 CYP2C19
Gene Expression Regulation, Enzymologic
Molecular Structure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Platelet Aggregation

Platelet Aggregation Inhibitors

Polymorphism, Single Nucleotide

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PMID: 34803003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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