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Article

PAPPA’s role in female reproduction

4 Jul 2025

Abstract excerpt

In brief: This review represents a multispecies summary of the role of pappalysins in female reproductive health. It discusses the potential use of PAPPA and PAPPA2 as biomarkers for oocyte and embryo quality and fetal development. Abstract: Pappalysin 1 and 2 (PAPPA and PAPPA2) are metzincin metalloproteinases expressed in the ovaries, endometrium, placenta, and several other organs. These enzymes are...

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Reproductive Biology and Fertility
TGF-β signaling in diseases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40683301
DOI: 10.1530/rep-25-0012

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