Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive Analysis of PAPPA2 Expression and Genetic Variants in Sheep and Their Association With Litter Size.

Veterinary medicine and science - 1 Jan 2026

Wang Yuanyuan, Xu Wenqiang, Liang Benmeng, Li Shujing, Hu Wenping, Chu Mingxing

Abstract excerpt

BACKGROUND: The PAPPA2 gene encodes a metalloproteinase critical for regulating insulin-like growth factor (IGF) bioavailability through cleavage of insulin-like growth factor-binding protein 5 (IGFBP5). While its role in human and murine reproduction is documented, its function in sheep reproductive traits remains underexplored. OBJECTIVE: This study aimed to investigate the differential expression patterns and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Litter Size
Share to Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Sheep, Domestic

Source

Open in PubMed Open full text

Identifiers

PMID: 41563143
DOI: 10.1002/vms3.70793
PMCID: PMC12822394

Genes

PAPPA2
IGFBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive Analysis of PAPPA2 Expression and Genetic Variants in Sheep and Their Association With Litter Size.PMID 41563143Read ↗

Multiomics Analyses Provide New Insight into Genetic Variation of Reproductive Adaptability in Tibetan Sheep.Semantic proximity Read ↗

Genetic variant of the sheep E2F8 gene and its associations with litter size.Semantic proximity Read ↗

Polymorphism, expression and structure analysis of key genes in the ovarian steroidogenesis pathway in sheep (Ovis aries).Semantic proximity Read ↗

Identification of genes associated with litter size combining genomic approaches in Luzhong mutton sheep.Semantic proximity Read ↗

Detection of polymorphisms in six genes and their association analysis with litter size in sheep.Semantic proximity Read ↗

The novel C268A variant of BMP2 is linked to the reproductive performance of Awassi and Hamdani sheep.Semantic proximity Read ↗

Sheep litter size heredity basis using genome-wide selective analysis.Semantic proximity Read ↗

Meta-analysis of genome-wide association studies for litter size in sheep.Semantic proximity Read ↗

Polymorphisms in BMPRIB gene affect litter size in Chinese indigenous sheep breed.Semantic proximity Read ↗

Expression and Polymorphisms of SMAD1, SMAD2 and SMAD3 Genes and Their Association with Litter Size in Tibetan Sheep (Ovis aries).Semantic proximity Read ↗

TGIF1 and SF1 polymorphisms are associated with litter size in Small Tail Han sheep.Semantic proximity Read ↗

PAPPA’s role in female reproductionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.