Differential Proteome Profiling Analysis under Pesticide Stress by the Use of a Nano-UHPLC-MS/MS Untargeted Proteomic-Based Approach on a 3D-Developed Neurospheroid Model: Identification of Protein Interactions, Prognostic Biomarkers, and Potential Therapeutic Targets in Human IDH Mutant High-Grade Gliomas.

doi:10.1021/acs.jproteome.3c00395

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Differential Proteome Profiling Analysis under Pesticide Stress by the Use of a Nano-UHPLC-MS/MS Untargeted Proteomic-Based Approach on a 3D-Developed Neurospheroid Model: Identification of Protein Interactions, Prognostic Biomarkers, and Potential Therapeutic Targets in Human IDH Mutant High-Grade Gliomas.

Journal of proteome research - 3 Nov 2023

Louati Kaouthar, Maalej Amina, Kolsi Fatma, Kallel Rim, Gdoura Yassine, Borni Mahdi, Hakim Leila Sellami, Zribi Rania, Choura Sirine, Sayadi Sami, Chamkha Mohamed, Mnif Basma, Khemakhem Zouheir, Boudawara Tahya Sellami, Boudawara Mohamed Zaher, Safta Fathi

Abstract excerpt

High-grade gliomas represent the most common group of infiltrative primary brain tumors in adults associated with high invasiveness, agressivity, and resistance to therapy, which highlights the need to develop potent drugs with novel mechanisms of action. The aim of this study is to reveal changes in proteome profiles under stressful conditions to identify prognostic biomarkers and altered apoptogenic pathways...

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PMID: 37651309
DOI: 10.1021/acs.jproteome.3c00395
PMCID: PMC10629271

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Differential Proteome Profiling Analysis under Pesticide Stress by the Use of a Nano-UHPLC-MS/MS Untargeted Proteomic-Based Approach on a 3D-Developed Neurospheroid Model: Identification of Protein Interactions, Prognostic Biomarkers, and Potential Therapeutic Targets in Human IDH Mutant High-Grade Gliomas.PMID 37651309Read ↗

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