A system perspective on drug response.

Abstract excerpt

The effect of drug perturbation(s) is quantified by measuring a specific phenotype. While drug action occurs on a molecular (microscopic) level, the measured phenotypes typically characterise system-level (macroscopic) variables, such as blood pressure or cell viability. Existing drug perturbation models are designed to infer (dosage-dependent) drug effects on the phenotype by analysis of the drug-induced changes...

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