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Antiviral Monocytes Increase Prior to Detectable HIV-1 Rebound Viremia

8 Jul 2025

Abstract excerpt

The persistence of human immunodeficiency virus 1 (HIV-1) proviruses in latently infected cells allows viremia to resume upon treatment cessation. To characterize the resulting immune response, we compared plasma proteomics and single-cell transcriptomics of peripheral blood mononuclear cells before, during, and after detectable plasma viremia. We observed unique transcriptional signatures prior to viral rebound,...

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PMID: 40628395
DOI: 10.1093/infdis/jiaf367

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