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NMR-Metabolomic Profiling and Genome Mining Drive the Discovery of Cyclic Decapeptides from a Marine Streptomyces

6 Sept 2023

Abstract excerpt

The integration of NMR-metabolomic and genomic analyses can provide enhanced identification of structural properties as well as key biosynthetic information, thus achieving the targeted discovery of new natural products. For this purpose, NMR-based metabolomic profiling of the marine-derived Streptomyces sp. S063 (CGMCC 14582) was performed, by which N -methylated peptides possessing unusual negative 1 H NMR...

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PMID: 37672645
DOI: 10.1021/acs.jnatprod.3c00310

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