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Differentiation therapy with hepatocyte nuclear factor 4α for patients with hepatocellular carcinoma

4 Jul 2025

Abstract excerpt

Differentiation therapy is an approach designed to revert tumor cells to a normal cellular state, thereby adopting benign characteristics. 1 This approach has achieved hallmark success in treating acute promyelocytic leukemia (APL) but has limited effectiveness in solid tumors. This difference in therapeutic efficacy may be due to the genetic complexity of the development of most solid tumors, which involve...

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PMID: 40615636
DOI: 10.1038/s41422-025-01142-3

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