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Article

The symptom complex of familial sinus node dysfunction and myocardial noncompaction is associated with mutations in the HCN4 channel.

Journal of the American College of Cardiology - 26 Aug 2014

Schweizer Patrick A, Schröter Julian, Greiner Sebastian, Haas Jan, Yampolsky Pessah, Mereles Derliz, Buss Sebastian J, Seyler Claudia, Bruehl Claus, Draguhn Andreas, Koenen Michael, Meder Benjamin, Katus Hugo A, Thomas Dierk

Abstract excerpt

BACKGROUND: Inherited arrhythmias were originally considered isolated electrical defects. There is growing evidence that ion channel dysfunction also contributes to myocardial disorders, but genetic overlap has not been reported for sinus node dysfunction (SND) and noncompaction cardiomyopathy (NCCM). OBJECTIVES: The study sought to investigate a familial electromechanical disorder characterized by SND and NCCM,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Defects, Congenital

Share to Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

Share to Membrane Potentials

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Source

Identifiers

PMID: 25145518
DOI: 10.1016/j.jacc.2014.06.1155

Genes

HCN4
CSRP3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The symptom complex of familial sinus node dysfunction and myocardial noncompaction is associated with mutations in the HCN4 channel.PMID 25145518Read ↗

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