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Article

Arsenite alters global histone H3 methylation

5 Mar 2008

Abstract excerpt

Arsenic (As) is a well-characterized human carcinogen but is generally not mutagenic. The evidence that As induces both loss of global DNA methylation and gene promoter DNA hypermethylation has suggested that epigenetic mechanisms may play an important role in As-induced carcinogenesis. In the present study, we examined the change in histone methylation by As exposure. In human lung carcinoma A549 cells, exposure...

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PMID: 18321869
DOI: 10.1093/carcin/bgn063

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