Article
Differences in Cerebral Glucose Metabolism in ALS Patients with and without C9orf72 and SOD1 Mutations.
Cells - 18 Mar 2023
De Vocht Joke, Van Weehaeghe Donatienne, Ombelet Fouke, Masrori Pegah, Lamaire Nikita, Devrome Martijn, Van Esch Hilde, Moisse Mathieu, Koole Michel, Dupont Patrick, Van Laere Koen, Van Damme Philip
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is characterized by progressive loss of upper and lower motor neurons. In 10% of patients, the disorder runs in the family. Our aim was to study the impact of ALS-causing gene mutations on cerebral glucose metabolism. Between October 2010 and October 2022, 538 patients underwent genetic testing for mutations with strong evidence of causality for ALS and...
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