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Article

Location of LMNA Variants and Clinical Outcomes in Cardiomyopathy

2 Jul 2025

Abstract excerpt

Importance: Prior studies have suggested that patients with nonmissense (ie, truncating) variants causing LMNA cardiomyopathy have worse arrhythmic outcomes compared to those with missense variants. However, the effect of the spatial distribution of missense and truncating variants on clinical outcomes remains poorly understood. Objective: To determine the association of the spatial distribution of missense and...

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Identifiers

PMID: 40601341
DOI: 10.1001/jamacardio.2025.2069

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