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Article

Domain-specific association of single-nucleotide variants in the LMNA gene with the phenotypic expression of dilated cardiomyopathy.

International journal of cardiology - 1 Apr 2025

Zhuo Wen, Jiang Zhenhong, Xun Mengwei, Lin Mouwen, Zhou Qiongqiong, Marian Ali J, Hong Kui

Abstract excerpt

BACKGROUND: LMNA gene variants cause a spectrum of phenotypes referred to as laminopathies. However, the topological distribution of the LMNA variants and their phenotypic effects have not been delineated. We investigated the associations of variants located at different LMNA domains with clinical phenotypes in dilated cardiomyopathy (DCM) patients. METHODS: All reported single-nucleotide variants (SNVs) in LMNA...

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Topics

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Share to Cardiomyopathy, Dilated
Share to LMNA gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RYR2 gene

Share to Lamin Type A

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Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 39923945
DOI: 10.1016/j.ijcard.2025.133043

Genes

LMNA
RYR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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