Variant-Specific Late Gadolinium Enhancement Patterns Influence Clinical Outcomes in LMNA-Related Cardiomyopathy.

doi:10.1161/JAHA.124.041230

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Article

Variant-Specific Late Gadolinium Enhancement Patterns Influence Clinical Outcomes in LMNA-Related Cardiomyopathy.

Journal of the American Heart Association - 5 Aug 2025

Castrichini Matteo, Garmany Ramin, Siontis Konstantinos C, Collins Jeremy D, Bois John P, Pereira Naveen L, Tester David J, Gluscevic Martina, Huynh Trung, Neves Raquel, Rosenbaum Andrew N, Ackerman Michael J, Giudicessi John R

Abstract excerpt

BACKGROUND: Disease-causative variants in LMNA-encoded lamin A/C cause a genetic cardiomyopathy characterized by atrioventricular block, atrial fibrillation, ventricular arrhythmias, and systolic dysfunction. The influence of LMNA variant type/localization on late gadolinium enhancement (LGE) patterns and clinical outcomes remains unclear. METHODS: Retrospective analysis of 822 genotype-positive patients with...

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Identifiers

PMID: 40689545
DOI: 10.1161/JAHA.124.041230
PMCID: PMC12449980

Genes

LMNA

Variants

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