Article
Evaluation of Bridge Capture technology for mutation profiling in liquid biopsies of metastatic colorectal cancer patients.
Scientific reports - 1 Jul 2025
Ganesan Aparna, Korkiakoski Anttoni, Adamusová Simona, Musku Anna, Rantasalo Tuula, Laine Nea, Andersson Emma, Osterlund Emerik, Ovissi Ali, Halonen Päivi, Hirvonen Tatu, Kim Jorma, Laine Jukka, Silvoniemi Antti, Minn Heikki, Blomster Juuso, Anttonen Anna-Kaisa, Kytölä Soili, Osterlund Pia, Pursiheimo Juha-Pekka, Nummela Pirjo, Tamminen Manu, Ristimäki Ari
Abstract excerpt
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths, often presenting at an advanced stage with significant molecular heterogeneity. This is the first study to evaluate the performance of a novel next-generation sequencing (NGS)-based Bridge Capture technology for mutation profiling and minimal residual disease detection in circulating tumor (ct)DNA from metastatic colorectal cancer...
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