Circulating Cell-Free Tumor DNA Analysis of 50 Genes by Next-Generation Sequencing in the Prospective MOSCATO Trial.

doi:10.1158/1078-0432.CCR-15-2470

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Article

Circulating Cell-Free Tumor DNA Analysis of 50 Genes by Next-Generation Sequencing in the Prospective MOSCATO Trial.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2016

Jovelet Cécile, Ileana Ecaterina, Le Deley Marie-Cécile, Motté Nelly, Rosellini Silvia, Romero Alfredo, Lefebvre Celine, Pedrero Marion, Pata-Merci Noémie, Droin Nathalie, Deloger Marc, Massard Christophe, Hollebecque Antoine, Ferté Charles, Boichard Amélie, Postel-Vinay Sophie, Ngo-Camus Maud, De Baere Thierry, Vielh Philippe, Scoazec Jean-Yves, Vassal Gilles, Eggermont Alexander, André Fabrice, Soria Jean-Charles, Lacroix Ludovic

Abstract excerpt

PURPOSE: Liquid biopsies based on circulating cell-free DNA (cfDNA) analysis are described as surrogate samples for molecular analysis. We evaluated the concordance between tumor DNA (tDNA) and cfDNA analysis on a large cohort of patients with advanced or metastatic solid tumor, eligible for phase I trial and with good performance status, enrolled in MOSCATO 01 trial (clinical trial NCT01566019). EXPERIMENTAL...

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PMID: 26758560
DOI: 10.1158/1078-0432.CCR-15-2470

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