Arginine regulates the mucoid phenotype of hypervirulent Klebsiella pneumoniae.

Abstract excerpt

Hypervirulent Klebsiella pneumoniae causes severe community-acquired infections, with its mucoid phenotype resulting from altered capsular polysaccharide chain length. While both environmental and genetic factors influence mucoidy, the cues regulating it remain unclear. Here, we show that casamino acids enhance mucoidy without affecting total capsular polysaccharide levels. We show that arginine is both necessary...

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