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Article

Potential role of avibactam in restoring susceptibility in Escherichia coli with two copies of blaKPC-3 and PBP3 mutations.

Scientific reports - 1 Jul 2025

Giuliano Simone, Fox Valeria, Ferin Sara, Martini Luca, Angelini Jacopo, Bulfoni Michela, Krpan Beatrice, Gualandi Nicolò, Moreal Chiara, Perno Carlo Federico, Bernaschi Paola, Di Gennaro Ciro, Arcamone Celeste, Turco Sara, Stanziola Maria Cristina, Manzi Rosa, Curcio Francesco, Pipan Corrado, Tascini Carlo

Abstract excerpt

The emergence of carbapenemase-producing Enterobacterales represents a significant clinical challenge. Resistance mechanisms involve carbapenemase production, porin and efflux pump alterations, penicillin-binding protein (PBP) modifications, and biofilm formation. This study characterizes a KPC-producing Klebsiella pneumoniae and a concurrent Escherichia coli isolate harboring the same resistance genes, with E....

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Identifiers

PMID: 40595049
DOI: 10.1038/s41598-025-07624-z
PMCID: PMC12216380

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