Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced Susceptibility to Cefepime-Taniborbactam in Carbapenem-Resistant Klebsiella pneumoniae Attributed to Penicillin-Binding Protein 3 Modifications.

The Journal of infectious diseases - 13 Mar 2026

Zhang Baofang, Xu Wei, Zhang Xiaoxia, Zhang Quan, Cheng Mingliang, Zong Zhiyong, Ma Ke

Abstract excerpt

BACKGROUND: The recent emergence of a carbapenem-resistant Klebsiella pneumoniae (CRKP) strain from a clinical specimen resistant to cefepime-taniboractam (FEP-TAN) raises serious concerns, necessitating further investigation of its resistance mechanisms. METHODS: Three CRKP clinical isolates were investigated: 1 FEP-TAN-resistant colonizing strain (CRKP068) from a throat swab of a patient with lung infection and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carbapenem-Resistant Enterobacteriaceae

Share to Carbapenems

Share to Klebsiella Infections

Share to Klebsiella pneumoniae

Share to Microbial Sensitivity Tests

Share to Penicillin-Binding Proteins

Source

Identifiers

PMID: 41824652
DOI: 10.1093/infdis/jiaf463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced Susceptibility to Cefepime-Taniborbactam in Carbapenem-Resistant Klebsiella pneumoniae Attributed to Penicillin-Binding Protein 3 Modifications.PMID 41824652Read ↗

Potential role of avibactam in restoring susceptibility in Escherichia coli with two copies of blaKPC-3 and PBP3 mutations.Semantic proximity Read ↗

Resistance to Ceftazidime-Avibactam Is Due to Transposition of KPC in a Porin-Deficient Strain of Klebsiella pneumoniae with Increased Efflux ActivitySemantic proximity Read ↗

Genomic analysis and reconstruction of cefotaxime resistance in Streptococcus pneumoniae.Semantic proximity Read ↗

Molecular mechanisms responsible KPC-135-mediated resistance to ceftazidime-avibactam in ST11-K47 hypervirulent Klebsiella pneumoniaeSemantic proximity Read ↗

Antimicrobial resistance to ceftazidime involving loss of penicillin-binding protein 3 in <i>Burkholderia pseudomallei</i>Semantic proximity Read ↗

Ceftazidime/Avibactam-Resistant Klebsiella pneumoniae subsp. pneumoniae Isolates in a Tertiary Italian Hospital: Identification of a New Mutation of the Carbapenemase Type 3 (KPC-3) Gene Conferring Ceftazidime/Avibactam ResistanceSemantic proximity Read ↗

Cefepime-Taniborbactam and Ceftibuten-Ledaborbactam Maintain Activity Against KPC Variants that Lead to Ceftazidime-Avibactam ResistanceSemantic proximity Read ↗

Emergence of Ceftazidime-Avibactam Resistance Due to Plasmid-Borne blaKPC-3 Mutations during Treatment of Carbapenem-Resistant Klebsiella pneumoniae Infections.Semantic proximity Read ↗

Cefepime–taniborbactam and ceftibuten–ledaborbactam maintain activity against KPC variants that lead to ceftazidime–avibactam resistanceSemantic proximity Read ↗

Phenotypic detection of clinical isolates of Haemophilus influenzae with altered penicillin-binding protein 3.Semantic proximity Read ↗

Identification of Mutations in the mrdA Gene Encoding PBP2 That Reduce Carbapenem and Diazabicyclooctane Susceptibility of Escherichia coli Clinical Isolates with Mutations in ftsI (PBP3) and Which Carry bla NDM-1Semantic proximity Read ↗

Decreased susceptibility to cefepime/zidebactam among carbapenemase-producing Escherichia coli from Stockholm, Sweden with alterations in PBP2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.